RXLR effector diversity in Phytophthora infestans isolates determines recognition by potato resistance proteins; the case study AVR1 and R1.
Identifieur interne : 000681 ( Main/Exploration ); précédent : 000680; suivant : 000682RXLR effector diversity in Phytophthora infestans isolates determines recognition by potato resistance proteins; the case study AVR1 and R1.
Auteurs : Y. Du [République populaire de Chine, Pays-Bas] ; R. Weide [Pays-Bas] ; Z. Zhao [Pays-Bas, République populaire de Chine] ; P. Msimuko [Pays-Bas] ; F. Govers [Pays-Bas] ; K. Bouwmeester [Pays-Bas]Source :
- Studies in mycology [ 0166-0616 ] ; 2018.
Abstract
Late blight disease caused by the plant pathogenic oomycete pathogen Phytophthora infestans is one of the most limiting factors in potato production. P. infestans is able to overcome introgressed late blight resistance by adaptation of effector genes. AVR1 is an RXLR effector that triggers immune responses when recognized by the potato resistance protein R1. P. infestans isolates avirulent on R1 plants were found to have AVR1 variants that are recognized by R1. Virulent isolates though, lack AVR1 but do contain a close homologue of AVR1, named A-L, of which all variants escape recognition by R1. Co-expression of AVR1 and R1 in Nicotiana benthamiana results in a hypersensitive response (HR). In contrast, HR is not activated when A-L is co-expressed with R1. AVR1 and A-L are highly similar in structure. They share two W motifs and one Y motif in the C-terminal part but differ in the T-region, a 38 amino acid extension at the carboxyl-terminal tail of AVR1 lacking in A-L. To pinpoint what determines R1-mediated recognition of AVR1 we tested elicitor activity of AVR1 and A-L chimeric and deletion constructs by co-expression with R1. The T-region is important as it enables R1-mediated recognition of A-L, not only when fused to A-L but also via trans-complementation. Yet, AVR1 lacking the T-region is still active as an elicitor of HR, but this activity is lost when certain motifs are swapped with A-L. These data show that A-L circumvents R1 recognition not only because it lacks the T-region, but also because of differences in the conserved C-terminal effector motifs.
DOI: 10.1016/j.simyco.2018.01.003
PubMed: 29910515
PubMed Central: PMC6002335
Affiliations:
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Du</name><affiliation wicri:level="1"><nlm:affiliation>College of Horticulture, Northwest A&F University, Yangling, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Horticulture, Northwest A&F University, Yangling</wicri:regionArea><wicri:noRegion>Yangling</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Weide, R" sort="Weide, R" uniqKey="Weide R" first="R" last="Weide">R. Weide</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Zhao, Z" sort="Zhao, Z" uniqKey="Zhao Z" first="Z" last="Zhao">Z. Zhao</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Industrial Crops Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Industrial Crops Institute, Yunnan Academy of Agricultural Sciences, Kunming</wicri:regionArea><wicri:noRegion>Kunming</wicri:noRegion></affiliation></author><author><name sortKey="Msimuko, P" sort="Msimuko, P" uniqKey="Msimuko P" first="P" last="Msimuko">P. Msimuko</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Govers, F" sort="Govers, F" uniqKey="Govers F" first="F" last="Govers">F. Govers</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author><author><name sortKey="Bouwmeester, K" sort="Bouwmeester, K" uniqKey="Bouwmeester K" first="K" last="Bouwmeester">K. Bouwmeester</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory of Phytopathology, Wageningen University, Wageningen</wicri:regionArea><orgName type="university">Université de Wageningue</orgName><placeName><settlement type="city">Wageningue</settlement><region nuts="2">Gueldre (province)</region></placeName></affiliation></author></analytic><series><title level="j">Studies in mycology</title><idno type="ISSN">0166-0616</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Late blight disease caused by the plant pathogenic oomycete pathogen <i>Phytophthora infestans</i> is one of the most limiting factors in potato production. <i>P. infestans</i> is able to overcome introgressed late blight resistance by adaptation of effector genes. AVR1 is an RXLR effector that triggers immune responses when recognized by the potato resistance protein R1. <i>P. infestans</i> isolates avirulent on R1 plants were found to have AVR1 variants that are recognized by R1. Virulent isolates though, lack AVR1 but do contain a close homologue of AVR1, named A-L, of which all variants escape recognition by R1. Co-expression of <i>AVR1</i> and <i>R1</i> in <i>Nicotiana benthamiana</i> results in a hypersensitive response (HR). In contrast, HR is not activated when <i>A-L</i> is co-expressed with <i>R1</i>. AVR1 and A-L are highly similar in structure. They share two W motifs and one Y motif in the C-terminal part but differ in the T-region, a 38 amino acid extension at the carboxyl-terminal tail of AVR1 lacking in A-L. To pinpoint what determines R1-mediated recognition of AVR1 we tested elicitor activity of AVR1 and A-L chimeric and deletion constructs by co-expression with R1. The T-region is important as it enables R1-mediated recognition of A-L, not only when fused to A-L but also via trans-complementation. Yet, AVR1 lacking the T-region is still active as an elicitor of HR, but this activity is lost when certain motifs are swapped with A-L. These data show that A-L circumvents R1 recognition not only because it lacks the T-region, but also because of differences in the conserved C-terminal effector motifs.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29910515</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0166-0616</ISSN><JournalIssue CitedMedium="Print"><Volume>89</Volume><PubDate><Year>2018</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Studies in mycology</Title><ISOAbbreviation>Stud Mycol</ISOAbbreviation></Journal><ArticleTitle>RXLR effector diversity in <i>Phytophthora infestans</i> isolates determines recognition by potato resistance proteins; the case study AVR1 and R1.</ArticleTitle><Pagination><MedlinePgn>85-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.simyco.2018.01.003</ELocationID><Abstract><AbstractText>Late blight disease caused by the plant pathogenic oomycete pathogen <i>Phytophthora infestans</i> is one of the most limiting factors in potato production. <i>P. infestans</i> is able to overcome introgressed late blight resistance by adaptation of effector genes. AVR1 is an RXLR effector that triggers immune responses when recognized by the potato resistance protein R1. <i>P. infestans</i> isolates avirulent on R1 plants were found to have AVR1 variants that are recognized by R1. Virulent isolates though, lack AVR1 but do contain a close homologue of AVR1, named A-L, of which all variants escape recognition by R1. Co-expression of <i>AVR1</i> and <i>R1</i> in <i>Nicotiana benthamiana</i> results in a hypersensitive response (HR). In contrast, HR is not activated when <i>A-L</i> is co-expressed with <i>R1</i>. AVR1 and A-L are highly similar in structure. They share two W motifs and one Y motif in the C-terminal part but differ in the T-region, a 38 amino acid extension at the carboxyl-terminal tail of AVR1 lacking in A-L. To pinpoint what determines R1-mediated recognition of AVR1 we tested elicitor activity of AVR1 and A-L chimeric and deletion constructs by co-expression with R1. The T-region is important as it enables R1-mediated recognition of A-L, not only when fused to A-L but also via trans-complementation. Yet, AVR1 lacking the T-region is still active as an elicitor of HR, but this activity is lost when certain motifs are swapped with A-L. These data show that A-L circumvents R1 recognition not only because it lacks the T-region, but also because of differences in the conserved C-terminal effector motifs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Horticulture, Northwest A&F University, Yangling, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weide</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Z</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Industrial Crops Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Msimuko</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Govers</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouwmeester</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>02</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Stud Mycol</MedlineTA><NlmUniqueID>8411984</NlmUniqueID><ISSNLinking>0166-0616</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Effector variation</Keyword><Keyword MajorTopicYN="N">Effector-triggered immunity (ETI)</Keyword><Keyword MajorTopicYN="N">Host defence</Keyword><Keyword MajorTopicYN="N">Late blight disease</Keyword><Keyword MajorTopicYN="N">Nucleotide-binding and leucine-rich repeat (NLR) protein</Keyword><Keyword MajorTopicYN="N">Potato resistance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>6</Month><Day>19</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29910515</ArticleId><ArticleId IdType="doi">10.1016/j.simyco.2018.01.003</ArticleId><ArticleId IdType="pii">S0166-0616(18)30003-4</ArticleId><ArticleId IdType="pmc">PMC6002335</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Plant Cell. 2009 Sep;21(9):2928-47</Citation><ArticleIdList><ArticleId IdType="pubmed">19794118</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Plant Microbe Interact. 2008 Nov;21(11):1460-70</Citation><ArticleIdList><ArticleId 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Chine</li></country><region><li>Gueldre (province)</li></region><settlement><li>Wageningue</li></settlement><orgName><li>Université de Wageningue</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Du, Y" sort="Du, Y" uniqKey="Du Y" first="Y" last="Du">Y. Du</name></noRegion><name sortKey="Zhao, Z" sort="Zhao, Z" uniqKey="Zhao Z" first="Z" last="Zhao">Z. Zhao</name></country><country name="Pays-Bas"><region name="Gueldre (province)"><name sortKey="Du, Y" sort="Du, Y" uniqKey="Du Y" first="Y" last="Du">Y. Du</name></region><name sortKey="Bouwmeester, K" sort="Bouwmeester, K" uniqKey="Bouwmeester K" first="K" last="Bouwmeester">K. Bouwmeester</name><name sortKey="Govers, F" sort="Govers, F" uniqKey="Govers F" first="F" last="Govers">F. Govers</name><name sortKey="Msimuko, P" sort="Msimuko, P" uniqKey="Msimuko P" first="P" last="Msimuko">P. Msimuko</name><name sortKey="Weide, R" sort="Weide, R" uniqKey="Weide R" first="R" last="Weide">R. Weide</name><name sortKey="Zhao, Z" sort="Zhao, Z" uniqKey="Zhao Z" first="Z" last="Zhao">Z. Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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